A Modern Overview of the Potential Therapeutic Effects of Psilocybin in the Treatment of Depressive Disorders, Treatment-Resistant Depression, and End-of-Life Distress
Cureus March 17, 2025 Fejzic Dino 1 citation
Psilocybin, a psychedelic alkaloid from Psilocybe mushrooms, shows therapeutic potential for conditions including treatment-resistant depression and end-of-life distress. This review consolidates current data on its efficacy, safety, therapeutic effects, indications, contraindications, drug interactions, adverse reactions, pharmacokinetics, pharmacodynamics, and dosing regimens. The evidence suggests psilocybin can produce rapid and sustained antidepressant effects, though its use requires careful screening and professional supervision due to risks such as anxiety, transient hypertension, and potential for adverse psychological reactions. The review provides a comprehensive pharmaceutical reference for clinicians and researchers.