Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis.
Frontiers in immunology January 1, 2025 David Qixiang Chen, José Adalberto Inzunza Domínguez, Juan Manuel Valle Uzeta et al. 3 citations
Ibogaine treatment in two multiple sclerosis patients led to substantial lesion shrinkage and decreased Apparent Diffusion Coefficient values, suggesting remyelination and reduced inflammation. Both patients showed cortical and subcortical alterations, especially in regions linked to pain and emotional processing. These findings indicate ibogaine may promote neuroplasticity and modulate neurocircuitry involved in MS pathology.