Environmentally friendly screen-printed electrodes for the selective detection of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in forensic analysis.
Analytical methods : advancing methods and applications November 14, 2024 Anne Alves Macedo, Dilton Martins Pimentel, Larissa Magalhães de Almeida Melo et al. 6 citations
Discarded screen-printed electrodes can be recoated with a graphite and chitosan mixture to create a reusable sensor for detecting the recreational drug 2C-B in oral fluid and seized samples. The sensor, called SPE-Gr/CTS, detects 2C-B electrochemically with a linear range from 0.05 to 7.5 μmol L⁻¹ and a detection limit of 0.015 μmol L⁻¹. Responses are stable across different electrodes, with relative standard deviation below 5.0%. The method is selective for 2C-B even when seventeen other illicit drugs or adulterants are present. Real seized and oral fluid samples were analyzed, and results matched those from LC-MS. The device offers a rapid, portable, and environmentally friendly screening tool for forensic analysis, using only 50 μL of sample.