Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep.
Psychopharmacology July 1, 2024 Juan Pedro Castro-Nin, Diego Serantes, Paola Rodriguez et al. 4 citations
Noribogaine, the main metabolite of the psychedelic ibogaine, promotes wakefulness while reducing slow-wave sleep and blocking REM sleep in rats, according to polysomnographic recordings. This pattern of sleep/wake alterations is similar to that previously reported for ibogaine itself. The findings provide new evidence on how iboga alkaloids act in the brain, suggesting that noribogaine contributes to the sleep-suppressing effects observed after ibogaine administration.