A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets.
Translational psychiatry January 19, 2024 Judit Biosca-Brull, Genis Ona, Lineth Alarcón-franco et al. 5 citations
A single oral dose of ibogaine significantly alters gene expression in the frontal cortex of mice four hours after administration. Genes involved in hormonal pathways and synaptogenesis were upregulated, while genes associated with apoptosis and endosomal transport were downregulated. Validation via qPCR did not fully confirm the hormonal pathway changes, possibly due to the specific brain region sampled. Female mice showed more pronounced gene expression changes than males, and high variability was observed across individual animals. These findings advance understanding of ibogaine's molecular actions and highlight sex differences that may influence its effects.