Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion.
Frontiers in pain research (Lausanne, Switzerland) January 1, 2023 Jonathan E Dickinson, Jose Adalberto Dominguez Inzunza, Liliana Perez-Villa et al. 3 citations
A 53-year-old man with two decades of severe, intractable neuropathic pain from brachial plexus nerve root avulsion due to vehicular trauma was successfully treated with both high-dose inpatient and low-dose outpatient ibogaine. Ibogaine, an indole alkaloid, acts on multiple neurotransmitter systems (NMDA, κ- and µ-opioid, σ2 receptors) and stimulates neurotrophic factors GDNF and BDNF. While promising, the adverse effects of high-dose ibogaine may limit its tolerability to the most refractory cases.