James O Fajemiroye

Instituto de Ciências Biológicas, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil; Graduate Program in Pharmaceutical Sciences, Campus Arthur Wesley Archibald, Evangelical University of Goiás, Anápolis 75083-515, Brazil. Electronic address: jamesfajemiroye@ufg.br.

2 papers in the library · 20 citations · publishing 2019-2023

Papers

Cutting-Edge Search for Safer Opioid Pain Relief: Retrospective Review of Salvinorin A and Its Analogs.

Frontiers in psychiatry January 1, 2019 Jordan K Zjawiony, Antônio S Machado, Ricardo Menegatti et al. 18 citations

Pain reduces quality of life, health, and economic well-being. Opioids are effective analgesics but cause side effects and have contributed to an overuse crisis, prompting the search for new pain treatments. This review examines salvinorin A and its analogs, focusing on their structural and pharmacological profiles as a basis for developing safer analgesics. Ethnopharmacological reports and preclinical data show antinociceptive effects of salvinorin A and some analogs. Analogs modified at the C-2 position dominate the literature. Binding affinity correlates with chemical structure and in vivo effects. Salvinorin A's susceptibility to chemical modification makes it a valuable tool for probing cellular mechanisms and developing promising analgesic analogs, though more research is needed to confirm therapeutic potential.

DOI: 10.3389/fpsyt.2019.00157 Full text Analgesic Analogs Opioid receptors Salvinorin a +1

Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects.

Fitoterapia June 1, 2023 Caroline V L Moreira, Ana Luiza G Faria, Daiany P B Silva et al. 2 citations

A new compound called P-3l, an analogue of salvinorin A, reduces pain and anxiety-like behaviors in mice after oral administration at doses of 1, 3, 10, and 30 mg/kg. It lessened acetic acid-induced writhing, formalin-induced paw licking, hotplate responses, and aversion in elevated plus-maze, open field, and light-dark box tests. P-3l also boosted the effects of morphine and diazepam at low doses without causing changes in organ weight or blood parameters. The pain and anxiety relief were blocked by naloxone, naloxonazine, nor-binaltorphimine, and flumazenil, indicating involvement of opioid receptors and the benzodiazepine site. These findings suggest P-3l may have clinical potential for pain and anxiety treatment.

DOI: 10.1016/j.fitote.2023.105488 Full text Antinociceptive Anxiolytic Benzodiazepine site Opioid receptors +14