Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects.
Fitoterapia June 1, 2023 Caroline V L Moreira, Ana Luiza G Faria, Daiany P B Silva et al. 2 citations
A new compound called P-3l, an analogue of salvinorin A, reduces pain and anxiety-like behaviors in mice after oral administration at doses of 1, 3, 10, and 30 mg/kg. It lessened acetic acid-induced writhing, formalin-induced paw licking, hotplate responses, and aversion in elevated plus-maze, open field, and light-dark box tests. P-3l also boosted the effects of morphine and diazepam at low doses without causing changes in organ weight or blood parameters. The pain and anxiety relief were blocked by naloxone, naloxonazine, nor-binaltorphimine, and flumazenil, indicating involvement of opioid receptors and the benzodiazepine site. These findings suggest P-3l may have clinical potential for pain and anxiety treatment.