1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?
Frontiers in psychiatry January 1, 2021 Sylvana Vilca-Melendez, Malin V Uthaug, Julian L Griffin 5 citations
A systematic review found that proton nuclear magnetic resonance (1H NMR) spectroscopy has been used primarily for structural elucidation and analytical characterization of psychedelic molecules such as psilocin, LSD, DMT, and bufotenin, but no studies have applied 1H NMR to metabolic profiling of biofluids in psychedelic research, revealing a research gap. The review compared 1H NMR with mass spectrometry, noting both techniques are suitable for biofluid analysis in other fields. Future directions identified include real-time NMR, in vivo magnetic resonance spectroscopy, and gut microbiome studies. Further research is needed to determine whether 1H NMR will be an effective approach for analyzing metabolites in peripheral biofluids and in vivo.