In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
Chemistry - A European Journal April 9, 2025 Tim Schäfer, Thomas Krüger, Jakob Worbs et al. 2 citations
A reusable solid-phase resin coated with five enzymes—three from Psilocybe mushrooms and two from E. coli—converts 4-hydroxy-L-tryptophan into psilocybin quantitatively in a proof-of-principle in vitro experiment. This biocatalytic approach offers a sustainable, selective alternative to synthetic production for the drug candidate being tested in advanced clinical trials for major depressive disorder.