Novel Psychoactive Phenethylamines: Impact on Genetic Material.
International journal of molecular sciences December 17, 2020 Veronica Cocchi, Sofia Gasperini, Patrizia Hrelia et al. 32 citations
Several psychedelic and stimulating phenethylamines, including 2C-H, 2C-I, 2C-B, and 25B-NBOMe, but not MDMA, damaged DNA in a human cell line (TK6 cells). The genetic damage was detected as an increase in micronucleus frequency. All genotoxic substances also elevated reactive oxygen species (ROS) levels, suggesting ROS production as a likely mechanism. Even at doses that do not cause immediate severe harm, exposure to these substances may still pose long-term risks through genotoxicity.