Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae).
Chemistry & biodiversity July 1, 2019 Felix Krengel, Marco V Mijangos, Marisol Reyes-Lezama et al. 17 citations
Methanol effectively extracts the antiaddictive alkaloids coronaridine, ibogamine, voacangine, and ibogaine (the CIVI-complex) from the root barks of Mexican Tabernaemontana alba and Tabernaemontana arborea. A one-step demethoxycarbonylation process then converts coronaridine and voacangine directly into ibogamine and ibogaine, simplifying the mixture from four to two major compounds. This protocol improves qualitative and quantitative analysis and offers a viable method for bulk production of these therapeutically important substances from these promising plant sources.