Metabolite Profiling of Anti-Addictive Alkaloids from Four Mexican Tabernaemontana Species and the Entheogenic African Shrub Tabernanthe iboga (Apocynaceae).
Chemistry & biodiversity April 1, 2019 Felix Krengel, Quentin Chevalier, Jonathan Dickinson et al. 10 citations
Ibogaine and related ibogan alkaloids, which show anti-addictive effects against drugs of abuse, occur in several Apocynaceae species. This work used gas chromatography-mass spectrometry and principal component analysis to compare alkaloid profiles of root and stem barks from four Mexican Tabernaemontana species with the root bark of the African shrub Tabernanthe iboga. Separation between species was attributed to quantitative differences in the major alkaloids coronaridine, ibogamine, voacangine, and ibogaine. T. iboga contained high concentrations of ibogaine, while Tabernaemontana samples showed predominance of either voacangine and ibogaine, or coronaridine and ibogamine. The results confirm that Mexican Tabernaemontana species are viable sources of anti-addictive compounds.