A 31-year-old male military veteran with moderate alcohol use disorder received sequential treatment with ibogaine hydrochloride (1550mg, 17.9mg/kg) on day 1 and vaporized 5-MeO-DMT (bufotoxin source 50mg, estimated 5-7mg) on day 3 at an inpatient clinic in Mexico. SPECT neuroimaging before and 3 days after treatment showed increased brain perfusion in bilateral caudate nuclei, left putamen, right insula, and temporal, occipital, and cerebellar regions. The patient reported improved mood, cessation of alcohol use, and reduced cravings at 5 days, sustained at 1 month, with partial return to mild alcohol use at 2 months. The findings suggest short-term therapeutic outcomes and warrant further investigation.
A single session of mindfulness meditation, whether 10 or 20 minutes, increases state mindfulness more than listening to a National Geographic article. The 10-minute meditation produced a greater increase in state mindfulness than its control, but there was no difference between the 10- and 20-minute meditation groups. People with lower trait mindfulness benefited more from meditation versus control in terms of state mindfulness. Among those with high trait mindfulness, the 20-minute meditation led to greater reductions in state anxiety than the 10-minute one. Overall, dose-response effects were minimal, suggesting 10 and 20 minutes of meditation improve state mindfulness comparably.