Mihajlo Spasić

Department of Physiology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Despota Stefana 142, 11000 Belgrade, Serbia.

2 papers in the library · 7 citations · publishing 2018-2019

Papers

The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes.

Oxidative medicine and cellular longevity January 1, 2018 Zorana Oreščanin-dušić, Nikola Tatalović, Teodora Vidonja-Uzelac et al. 7 citations

Ibogaine, an alkaloid from the African shrub Tabernanthe iboga, alters uterine muscle activity in a concentration-dependent way. Low concentrations stimulate spontaneous contractions, while higher doses inhibit them. Inhibitory doses reduce SOD1 activity and increase GSH-Px activity; complete inhibition raises CAT activity. These enzyme changes are due to posttranslational modifications, not altered protein levels, and point to a large rise in hydrogen peroxide. Since extracellular ATP stimulates uterine contractions and hydrogen peroxide inhibits them, ibogaine's dual effect likely stems from its known impact on cellular ATP levels and redox balance.

DOI: 10.1155/2018/5969486 Full text Ibogaine Compound Substance Addiction therapy +13

Effects of ibogaine treatment on redox homeostasis and energy metabolism in rat

IBRO Reports December 1, 2019 Nikola Tatalović, Teodora Vidonja Uzelac, Zorana Oreščanin-dušić et al.

A single oral dose of ibogaine (20 mg/kg) in female Wistar rats caused transient oxidative stress in the brain and depleted glycogen stores in the liver. Six hours after treatment, lipid peroxidation (TBARS) increased significantly, while after 24 hours it returned to control levels. Protein free sulfhydryl groups increased, but nonprotein free sulfhydryl groups (indicating reduced glutathione) decreased, both more pronounced at 24 hours. Despite these signs of oxidative stress, the activities of antioxidative enzymes (SOD, CAT, GSH-Px, GR) and glutathione S-transferases remained unchanged. Liver glycogen was reduced, more at 6 hours than at 24 hours, suggesting a transient depletion of energy reserves that begins to recover within a day. These findings suggest ibogaine induces rapid, reversible changes in redox and energy homeostasis.

DOI: 10.1016/j.ibror.2019.09.087 Energy metabolism Redox Homeostasis Chemistry +3