Effects of ibogaine treatment on redox homeostasis and energy metabolism in rat
IBRO Reports December 1, 2019 Nikola Tatalović, Teodora Vidonja Uzelac, Zorana Oreščanin-dušić et al.
A single oral dose of ibogaine (20 mg/kg) in female Wistar rats caused transient oxidative stress in the brain and depleted glycogen stores in the liver. Six hours after treatment, lipid peroxidation (TBARS) increased significantly, while after 24 hours it returned to control levels. Protein free sulfhydryl groups increased, but nonprotein free sulfhydryl groups (indicating reduced glutathione) decreased, both more pronounced at 24 hours. Despite these signs of oxidative stress, the activities of antioxidative enzymes (SOD, CAT, GSH-Px, GR) and glutathione S-transferases remained unchanged. Liver glycogen was reduced, more at 6 hours than at 24 hours, suggesting a transient depletion of energy reserves that begins to recover within a day. These findings suggest ibogaine induces rapid, reversible changes in redox and energy homeostasis.