Ann M Decker

2 papers in the library · 158 citations · publishing 2014-2018

Papers

Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes.

Psychopharmacology October 1, 2014 Bruce E Blough, Antonio Landavazo, Ann M Decker et al. 99 citations

Synthetic hallucinogenic tryptamines, including those originally described by Alexander Shulgin, are abused in the USA. While all psychoactive tryptamines act as agonists at serotonin 2A (5-HT₂A) receptors, their varied subjective effects suggest additional neurochemical mechanisms. This work evaluated 21 tryptamines for interactions with serotonin receptor subtypes and neurotransmitter transporters. Eight compounds released serotonin, thirteen inhibited serotonin uptake or were inactive. All were 5-HT₂A agonists with varying potencies; few activated 5-HT₁A receptors. Most recruited β-arrestin via 5-HT₂A. Serotonin transporter (SERT) activity may contribute significantly to some compounds' pharmacology. Releasers tended to be structurally smaller compounds. Two tertiary amines acted as selective SERT substrates, challenging the view that releasing activity requires primary or secondary amines.

DOI: 10.1007/s00213-014-3557-7 Full text Hallucinogens Psychedelics Psychoactive substances Hallucinogenic compounds +12

Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.

Neuropharmacology November 1, 2018 Joshua S Elmore, Ann M Decker, Agnieszka Sulima et al. 59 citations

N-methoxybenzylated derivatives of 2C compounds, specifically 25C-NBOMe and 25I-NBOMe, show higher affinity for 5-HT2A receptors than their parent 2C compounds but are weaker in functional cellular assays. In rats, NBOMes were much more potent at inducing wet dog shakes and back muscle contractions compared to 2C-C and 2C-I. A selective 5-HT2A antagonist reversed these behaviors, confirming receptor involvement. Binding affinities correlated with potencies for back muscle contractions but not wet dog shakes. These findings indicate NBOMes are highly potent 5-HT2A agonists in rats, consistent with reported hallucinogenic effects in humans.

DOI: 10.1016/j.neuropharm.2018.02.033 Full text 5-ht2a receptor Back muscle contractions Wet dog shakes Nbome compounds nbome +8