Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats.
Pharmacology, biochemistry, and behavior January 1, 2016 Amir H Rezvani, Marty C Cauley, Susan Slade et al. 22 citations
The ibogaine derivative 18-methoxycoronaridine (18-MC), given orally, reduced nicotine and alcohol self-administration in rats. In female rats trained to self-administer nicotine, a single 40 mg/kg oral dose significantly decreased nicotine intake, particularly in animals with lower baseline consumption. In alcohol-preferring rats of both sexes, 18-MC dose-dependently reduced alcohol intake, with all tested doses (10, 20, 40 mg/kg) producing significant reductions. These results indicate that oral 18-MC is effective in curbing both alcohol and nicotine seeking, supporting its potential as a therapy for alcoholism and smoking addiction.