Ibogaine and addiction in the animal model, a systematic review and meta-analysis.
Translational psychiatry May 31, 2016 M Belgers, M Leenaars, J R Homberg et al. 64 citations
Ibogaine, a naturally occurring substance used informally to reduce craving and relapse in substance use disorders, was evaluated in a systematic review and meta-analysis of 27 animal studies. Ibogaine reduced drug self-administration, especially within the first 24 hours after dosing, but did not affect drug-induced conditioned place preference. It caused motor impairment in the first day and cerebral cell loss persisting for weeks. Data on cardiac effects and neuropharmacological mechanisms were limited. The findings support further clinical research into ibogaine's efficacy for reducing craving and substance use in patients, but close monitoring is recommended due to potential toxic effects.