Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders.
Current drug abuse reviews January 1, 2014 R G Dos Santos, J A S Crippa, J P Machado-De-Sousa et al. 10 citations
Psychostimulant abuse and dependence currently lack pharmacological treatment. Salvinorin A, a κ-opioid receptor agonist from the plant Salvia divinorum used by Mazateca Indians, and its analogues have shown anti-addiction effects in animal models. These effects occur by attenuating dopamine release, sensitization, and other neurochemical and behavioral changes caused by acute and prolonged psychostimulant administration. The article presents an overview of preclinical evidence suggesting these anti-addictive properties.