Laurent Fanton

2 papers in the library · 39 citations · publishing 2018-2023

Papers

Unpredictable Behavior Under the Influence of “Magic Mushrooms”: A Case Report and Review of the Literature

Journal of Forensic Sciences December 12, 2018 Emma Honyiglo, Angélique Franchi, Nathalie Cartiser et al. 33 citations

A young man without psychiatric history died after jumping from a second-story balcony while under the influence of psilocybin mushrooms. Psilocin concentrations measured 60 ng/mL in peripheral blood, 67 ng/mL in cardiac blood, 2230 ng/mL in urine, 3102 ng/mL in bile, and 57 ng/mL in vitreous humor. The case and literature review demonstrate that even regular users in seemingly safe circumstances can suffer fatal outcomes from psilocybin mushrooms alone.

DOI: 10.1111/1556-4029.13982 Psilocybin Mushroom poisoning Solid phase extraction Medicine +2

α-Methyltryptamine (α-MT) Metabolite Profiling in Human Hepatocyte Incubations and Postmortem Urine and Blood

Metabolites January 6, 2023 Sara Malaca, Charline Bottinelli, Laurent Fanton et al. 6 citations

α-Methyltryptamine (α-MT) is a hallucinogenic and stimulant drug linked to overdose deaths. To identify biomarkers proving its use, metabolites were analyzed in lab-grown human liver cells and in urine and blood from a fatal overdose case. Nine metabolites formed in liver cells, with eight more in urine and five in blood. Transformations included hydroxylation, sulfation, glucuronidation, and acetylation. The liver cell model matched real samples, confirming its usefulness. Recommended urine biomarkers are α-MT, hydroxy-α-MT glucuronide, and two hydroxy-α-MT sulfates; blood biomarkers are α-MT, two hydroxy-α-MT sulfates, and N-acetyl-α-MT. More studies with varied doses are needed.

DOI: 10.3390/metabo13010092 Metabolite Glucuronidation Tryptamine Urine +12