Analysis of electrical brain waves in neurotoxicology: γ-hydroxybutyrate.
Current neuropharmacology March 1, 2011 Z K Binienda, M A Beaudoin, B T Thorn et al. 10 citations
Fast Fourier Transform (FFT) analysis of electrocorticogram (ECoG) recordings in conscious rats reveals that different drugs alter brainwave frequencies in distinct ways. Domoic acid administration links slow-wave delta and theta activity with behavioral seizure type. Ibogaine pretreatment before cocaine increases power in the alpha(1) band, suggesting serotonergic involvement, and lowers the threshold for cocaine-induced electrographic seizures by increasing delta and theta power. Two weeks of daily cocaine reduces slow-wave ECoG activity 24 hours after the last injection, mirroring reduced frontal cortex metabolism in chronic human users. Gamma-hydroxybutyrate (GHB) at 400 and 800 mg/kg increases energy across all except beta(2) bands, producing EEG patterns resembling absence seizures in human petit mal epilepsy.