Intramolecular transacetylation in salvinorins D and E.
Journal of natural products April 23, 2010 Lukasz M Kutrzeba, Xing-Cong Li, Yuanqing Ding et al. 23 citations
Fresh Salvia divinorum leaves yielded salvinorins E and D, which may be natural precursors to salvinorin A, a potent hallucinogen. During HPLC purification, salvinorin E spontaneously converted into a mixture with its regioisomer salvinorin D in a 3:5 ratio, observable by NMR. This isomerization occurs through a dynamic intramolecular transacetylation process.