Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys.
The Journal of pharmacology and experimental therapeutics April 1, 2010 Jun-Xu Li, Wouter Koek, Kenner C Rice et al. 17 citations
Serotonin (5-HT)1A receptor agonists attenuated the effects of the 5-HT2A receptor agonist DOM in rhesus monkeys but not in rats, indicating a species difference in how these receptor systems interact. DOM and other 5-HT2A agonists produced similar discriminative stimulus effects in both species, and these effects were blocked by a 5-HT2A antagonist. The 5-HT1A agonists 8-OH-DPAT and F13714 reduced DOM's effects only in monkeys, an effect prevented by a 5-HT1A antagonist. The findings suggest that while the DOM stimulus is mediated by 5-HT2A receptors in both species, the modulatory role of 5-HT1A receptors differs markedly between rats and monkeys, which has implications for studying drugs with multiple mechanisms.