Induction of energy metabolism related enzymes in yeast Saccharomyces cerevisiae exposed to ibogaine is adaptation to acute decrease in ATP energy pool.
European journal of pharmacology February 10, 2010 Roman Paskulin, Polona Jamnik, Natasa Obermajer et al. 13 citations
Ibogaine, known for its anti-addictive effects, alters energy metabolism in a way that is not species- or tissue-specific. In yeast (Saccharomyces cerevisiae) grown with 1 mg/l ibogaine for 5 hours, enzymes involved in energy production—glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, enolase, and alcohol dehydrogenase—were induced. This induction compensates for a drop in ATP levels observed after ibogaine exposure. The effect occurs without involvement of receptors, which are absent in yeast, indicating a direct metabolic influence rather than receptor-mediated action.