Inhaled salvinorin A, the active ingredient in Salvia divinorum, produces transient psychotomimetic and perceptual alterations including dissociative and somaesthetic effects, increases plasma cortisol and prolactin, and reduces resting electroencephalogram spectral power. It does not cause euphoria, cognitive deficits, or changes in vital signs, and the effects are not dose-related. The substance is very well-tolerated without acute or delayed adverse effects, and its lack of euphoric effects suggests a low addictive potential similar to other hallucinogens.
Intravenous THC, at doses from 0.015 to 0.05 mg/kg, produces time overestimation and underproduction in seconds-range tasks, indicating an increased internal clock speed. This effect is not dose related and is blunted in frequent cannabis smokers, who show no differences in time perception compared to infrequent or nonsmokers. Chronic cannabis use does not alter baseline time perception.