Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V June 1, 2009 Zeynep S Teksin, Insong J Lee, Noble N Nemieboka et al. 76 citations
Salvinorin A, a potent hallucinogen from Salvia divinorum, is rapidly eliminated after intraperitoneal dosing in rats, with a half-life of 75 minutes and a clearance of 26 L/h/kg. Its distribution is extensive (47.1 L/kg), but brain levels are low (brain-to-plasma ratio 0.050) and the brain half-life is only 36 minutes. In cell studies, salvinorin A is transported by P-glycoprotein and metabolized by several enzymes, including CYP2D6, CYP1A1, CYP2C18, CYP2E1, and UGT2B7. These findings align with the compound's fast onset and short duration of action.