Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil.
Synapse (New York, N.Y.) August 1, 2009 Philip Seeman, Hong-Chang Guan, Hélène Hirbec 83 citations
Phencyclidine and other hallucinogens and psychostimulants can activate dopamine D2 receptors in rat brain tissue, contrary to some earlier reports. Using rat striatum homogenates, phencyclidine achieved 46% of the maximum stimulation produced by dopamine, with a half-maximum concentration of 70 nM. Other compounds, including LSD, salvinorin A, R-modafinil, ketamine, and dizocilpine, also stimulated D2 receptors at concentrations related to their behavioral effects. The stimulation was blocked by a D2 antagonist and by hypertonic buffer containing sodium chloride, which may explain why previous studies failed to observe this effect.