The detection and quantitative analysis of the psychoactive component of Salvia divinorum, salvinorin A, in human biological fluids using liquid chromatography-mass spectrometry.
Journal of analytical toxicology January 1, 2008 Pamela C Mcdonough, Justin M Holler, Shawn P Vorce et al. 24 citations
A new analytical method using solid-phase extraction with liquid chromatography-electrospray ionization mass spectrometry accurately detects and quantifies the psychoactive compound salvinorin A in human blood and urine. The method reliably measures concentrations between 5.0 and 100 ng/mL, with a detection limit of 2.5 ng/mL and a quantitation limit of 5.0 ng/mL. It provides a robust tool for forensic toxicology to identify salvinorin A in biological fluids, addressing the lack of published methods and supporting research on the compound's health effects and pharmacokinetics.