Justin M Holler

Division of Forensic Toxicology, Armed Forces Medical Examiner System, Dover AFB, Dover, DE 19902, USA.

2 papers in the library · 58 citations · publishing 2008-2016

Papers

Detection of 25C-NBOMe in Three Related Cases.

Journal of analytical toxicology July 1, 2016 John J Kristofic, Jeffrey D Chmiel, George F Jackson et al. 34 citations

A 23-year-old Caucasian male died after being subdued by military law enforcement, having experienced severe respiratory distress. Autopsy revealed mild to moderate coronary atherosclerosis, biventricular dilation, mild right ventricular hypertrophy, and bilateral pulmonary edema and congestion. Blood contained no drugs or ethanol, but urine had pseudoephedrine, nicotine, and cotinine. A designer drug screen detected 25C-NBOMe, 25C-NBOH, and 2C-C in blood and urine. 25C-NBOMe concentrations were measured in blood (2.07 ng/mL), urine (27.43 ng/mL), and various organs. The medical examiner ruled the cause of death as 25C-NBOMe toxicity temporally associated with excited delirium and forcible restraint, manner accidental.

DOI: 10.1093/jat/bkw035 Full text

The detection and quantitative analysis of the psychoactive component of Salvia divinorum, salvinorin A, in human biological fluids using liquid chromatography-mass spectrometry.

Journal of analytical toxicology January 1, 2008 Pamela C Mcdonough, Justin M Holler, Shawn P Vorce et al. 24 citations

A new analytical method using solid-phase extraction with liquid chromatography-electrospray ionization mass spectrometry accurately detects and quantifies the psychoactive compound salvinorin A in human blood and urine. The method reliably measures concentrations between 5.0 and 100 ng/mL, with a detection limit of 2.5 ng/mL and a quantitation limit of 5.0 ng/mL. It provides a robust tool for forensic toxicology to identify salvinorin A in biological fluids, addressing the lack of published methods and supporting research on the compound's health effects and pharmacokinetics.

DOI: 10.1093/jat/32.6.417 Full text Salvinorin a detection Detecting salvinorin a Quantifies salvinorin a Detecting levels +15