Disposition of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and its metabolite 4-bromo-2-hydroxy-5-methoxyphenethylamine in rats after subcutaneous administration.
Toxicology letters April 21, 2008 Miroslava Rohanová, Tomás Pálenícek, Marie Balíková 33 citations
The psychedelic compound 2C-B, involved in human drug abuse and overdose cases, was studied in rats to determine its distribution and kinetics after subcutaneous injection. The drug had an estimated half-life of 1.1 hours and a volume of distribution of 16 L/kg. 2C-B entered the brain without significant delay, and its brain-to-serum ratio peaked at 13.9, remaining above 6.5 for six hours. The lungs showed a tendency to retain the drug and release it gradually over time, similar to the brain. The major metabolite 2H5M-BPEA was found in lung, brain, and liver tissues but distributed less efficiently into the brain than the parent compound. These findings help assess the drug's psychotropic and toxic effects.