New designer drug 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric and capillary electrophoretic/mass spectrometric techniques.
Journal of mass spectrometry : JMS July 1, 2006 Denis S Theobald, Michael Pütz, Erhard Schneider et al. 51 citations
The designer drug 2C-I is metabolized in rats through O-demethylation, deamination, oxidation, and reduction pathways, producing multiple metabolites that are partly excreted in conjugated form. A systematic toxicological analysis using gas chromatography/mass spectrometry after acid hydrolysis, liquid-liquid extraction, and microwave-assisted acetylation reliably detected a dose of 2C-I in rat urine equivalent to a common human drug user's dose. Assuming similar metabolism in humans, this detection method should be suitable for proving 2C-I intake in human urine.