Characterization of the discriminable stimulus produced by 2-BFI: effects of imidazoline I(2)-site ligands, MAOIs, beta-carbolines, agmatine and ibogaine.
British journal of pharmacology March 1, 2002 Nicholas Macinnes, Sheila L Handley 30 citations
Rats trained to distinguish the imidazoline I2-site ligand 2-BFI from saline showed that several compounds that reversibly inhibit monoamine oxidase A (MAO-A), including the anti-addictive drug ibogaine, produced similar internal cues, substituting for 2-BFI in a dose-dependent manner. In contrast, MAO-B inhibitors and other related compounds failed to substitute. The findings suggest that the subjective effects of I2-site ligands are linked to reversible MAO-A inhibition, likely through increased extracellular monoamine levels, and that ibogaine shares these subjective effects.