Iboga compounds reverse the behavioural disinhibiting and corticosterone effects of acute methamphetamine: Implications for their antiaddictive properties.
Pharmacology, biochemistry, and behavior January 1, 2001 K K Szumlinski, R E Haskew, M Y Balogun et al. 28 citations
Pretreatment with ibogaine or its synthetic derivative 18-methoxycoronaridine reversed the behavioral disinhibition and increased corticosterone levels caused by a low dose of methamphetamine in rats. Methamphetamine alone increased open-arm entries in the elevated plus maze and raised plasma corticosterone, suggesting behavioral disinhibition rather than anxiety reduction. Both iboga compounds blocked these effects without altering general locomotion, indicating a potential mechanism for their anti-addictive properties through modulation of neuroendocrine stress responses.