Extraction Yields of Psilocybin and Psilocin: A Short Review of Current Methods and Their Implications
Pharmaceuticals March 7, 2025 Taynah P Galdino, Lucas C Oliveira, Mateus A Luz et al. 11 citations
A systematic review of 25 studies on extracting and quantifying psilocybin and psilocin from Psilocybe mushrooms found that both the extraction method and mushroom species significantly affect compound yields. Ultrasonic bath extraction was the most efficient technique, especially for Psilocybe cyanescens and Psilocybe cubensis. High-performance liquid chromatography (HPLC) was the most common method for identifying and quantifying the compounds. Polar solvents were essential for effective solubilization, with temperature, solvent-to-material ratio, and extraction time being key parameters for optimizing yields. The review aims to support standardized protocols for ensuring compound quality and purity.