Long-lasting ibogaine protection against NMDA-induced convulsions in mice.
Neurochemical research August 1, 2000 M B Leal, D O De Souza, E Elisabetsky 23 citations
A single dose of ibogaine in mice produces a complex, long-lasting pattern of modulation of NMDA receptors, a brain receptor type involved in addiction. Ibogaine inhibited convulsions induced by NMDA at 24 and 72 hours after treatment, and binding to NMDA receptors was also significantly decreased at those times. No effects were seen at 30 minutes or 48 hours. This sustained, non-continuous modulation may underlie ibogaine's ability to reduce withdrawal and craving for extended periods after a single dose.