PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA.
Pharmacology, biochemistry, and behavior January 1, 2001 J B Rangisetty, M L Bondarev, J Chang-Fong et al. 14 citations
Psychoactive phenylisopropylamines can produce different stimulus effects in animals, typified by hallucinogen DOM, stimulant amphetamine, and the less understood agent PMMA. In rats trained to discriminate PMMA from vehicle, the PMMA stimulus generalized to both optical isomers of MBDB and 3,4-DMA, with S(+)-MBDB (ED50=0.8 mg/kg) more potent than R(-)-MBDB (2.0 mg/kg) and S(+)-3,4-DMA (2.6 mg/kg) more potent than R(-)-3,4-DMA (3.9 mg/kg). These agents produce stimulus effects similar to PMMA. Both isomers of 3,4-DMA substituted for an MDMA stimulus but not for DOM or amphetamine stimuli. The evidence suggests PMMA, both isomers of MBDB and 3,4-DMA, and S(+)-MDMA produce common stimulus effects in rats, better defining the PMMA stimulus and structural requirements for this effect.