Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry.
Journal of mass spectrometry : JMS June 1, 2005 Vilma Habrdova, Frank T Peters, Denis S Theobald et al. 61 citations
A new method using gas chromatography/mass spectrometry was developed to screen and quantify seven 2C-series designer drugs (2C-D, 2C-E, 2C-P, 2C-B, 2C-I, 2C-T-2, 2C-T-7) and mescaline in human blood plasma. The method involves solid-phase extraction and derivatization, and was validated per international guidelines. Validation for 2C-T-2 and 2C-T-7 was unacceptable; for the other analytes, the method was linear from 5 to 500 microg/L with accuracy and precision within acceptable limits. This addresses the scarcity of data on analyzing these substances in blood or plasma.