Determination of ibogaine and 12-hydroxy-ibogamine in plasma by gas chromatography-positive ion chemical ionization-mass spectrometry.
Journal of analytical toxicology October 1, 1995 M E Alburges, R L Foltz, D E Moody 19 citations
A new method was developed to measure ibogaine and its active metabolite, 12-hydroxy-ibogamine, in human plasma. The assay uses a one-step extraction and gas chromatography-mass spectrometry, achieving accurate measurements from 10 to 1000 ng/mL. Ibogaine and its metabolite remained stable in plasma for at least one week at room temperature. The method provides a reliable tool for studying ibogaine's potential in treating addiction.