The effects of ibogaine on dopamine and serotonin transport in rat brain synaptosomes.
Brain research bulletin April 1, 1999 G B Wells, M C Lopez, J C Tanaka 30 citations
Ibogaine blocks the uptake of dopamine and serotonin in rat brain synaptosomes, with stronger effects on serotonin (IC50 2.6 µM) than dopamine (IC50 20 µM). It inhibits potassium-induced serotonin release but not dopamine release, and triggers a small dopamine release without stimulation. These micromolar-range effects align with ibogaine's low binding affinity for dopamine and serotonin transporters, suggesting that if ibogaine's anti-addictive properties require such concentrations, they likely involve multiple neurotransmitter pathways.