A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS.
Journal of analytical toxicology September 1, 2004 Shawn P Vorce, Jason H Sklerov 79 citations
A gas chromatography-mass spectrometry method was developed to screen for six designer tryptamines and phenethylamines recently added to the DEA's controlled substances list. The method detects pentafluoropropionic derivatives of AMT, DMT, 2CB, DPT, 2C-T-7, and 5-MeO-DiPT, with detection limits of 5-10 ng/mL and linearity from 50 to 1000 ng/mL. It was successfully applied to blood and urine from suspected AMT intoxications. Confirmation of 5-MeO-DiPT in one subject's urine by liquid chromatography-mass spectrometry yielded a concentration of 229 ng/mL, with linearity from 25 to 1500 ng/mL and a detection limit of 5 ng/mL. Two additional peaks suggested metabolites 5-MeO-iPT and 5-MeO-DiPT-N-oxide.