Stimulus effects of three sulfur-containing psychoactive agents.
Pharmacology, biochemistry, and behavior August 1, 2004 Nantaka Khorana, Manik R Pullagurla, Malgorzata Dukat et al. 21 citations
Two sulfur-containing phenylalkylamines, 4-MTA and 2C-T-7, gaining popularity on the illicit drug market, were tested in rats trained to discriminate the hallucinogen DOM, the stimulant cocaine, or the empathogen MDMA from a neutral substance. 4-MTA and its analog 4-MTMA substituted only for MDMA, whereas 2C-T-7 substituted only for DOM. These results indicate that 4-MTA and 4-MTMA act like MDMA, while 2C-T-7 behaves like a DOM-like hallucinogen, extending knowledge of structure-activity relationships and aligning with limited human reports.