Enhancement of morphine antinociception by ibogaine and noribogaine in morphine-tolerant mice.
Pharmacology November 1, 1998 S Sunder Sharma, H N Bhargava 17 citations
In male Swiss-Webster mice, ibogaine and its metabolite noribogaine enhanced morphine's pain-relieving effect in animals that had developed tolerance to morphine, but not in those that had never received morphine. Tolerance was induced by implanting a 25 mg morphine pellet for three days. Both compounds dose-dependently increased morphine antinociception only in morphine-tolerant mice, suggesting they may help restore opioid effectiveness in tolerant states.