Alteration in Electroencephalogram and Monoamine Concentrations in Rat Brain following Ibogaine Treatment.
Annals of the New York Academy of Sciences May 1, 1998 Zbigniew Binienda, Michael A Beaudoin, Brett T Thorn et al. 13 citations
Ibogaine, a psychoactive alkaloid with antiaddictive properties, can cause neurotoxicity. In anesthetized rats, a single 50 mg/kg dose of ibogaine produced an immediate decrease in heart rate and reduced EEG power across delta, theta, alpha, and beta frequency bands during the first 30 minutes, with recovery within 15 minutes. In the caudate nucleus, dopamine levels fell while dopamine turnover increased; serotonin levels rose in the frontal cortex. These physiological changes likely stem from ibogaine's interactions with multiple neurotransmitter systems.