In Vivo Ibogaine Blockade and In Vitro PKC Action of Cocainea.
Annals of the New York Academy of Sciences May 1, 1998 Emmanuel S Onaivi, Syed F Ali, Amitabha Chakrabarti 13 citations
Ibogaine, a substance with potential antiaddiction effects against alcohol, psychostimulants, and opiates, was studied in mice and cell cultures to explore its mechanism. In mice, acute ibogaine doses reduced aversion to open arms in a plus-maze test, while subacute administration caused fluctuating aversive and antiaversive behavior over 14 days. Ibogaine reversed withdrawal aversions in mice abruptly withdrawn from cocaine. In PC 12 cells, cocaine disrupted signal transduction by altering protein kinase C isoform expression and activity and calcium levels. The findings suggest ibogaine's antiaddictive property may involve modifying central nervous system neurotransmission related to anxiety, but whether PKC signaling is important remains unknown.