Failure of ibogaine to produce phencyclidine-like discriminative stimulus effects in rats and monkeys.
Pharmacology, biochemistry, and behavior February 1, 1998 H E Jones, H Li, R L Balster 11 citations
Ibogaine did not produce effects similar to phencyclidine (PCP) in rats or rhesus monkeys trained to discriminate PCP from saline or sham injection. In rats, ibogaine showed no substitution for PCP at doses from 5.6 to 17.6 mg/kg. In monkeys, ibogaine also failed to generalize to PCP at doses from 0.5 to 4.0 mg/kg. Lysergic acid diethylamide (LSD) only partially substituted for PCP in rats and produced little PCP-associated lever pressing in monkeys. These results indicate important behavioral differences between PCP and hallucinogens like LSD and ibogaine and do not support the idea that ibogaine's binding to the PCP site on NMDA receptors drives its acute effects.