Ibogaine effects on sweet preference and amphetamine induced locomotion: implications for drug addiction.
Behavioural brain research December 1, 1997 J R Blackburn, K K Szumlinski 22 citations
Ibogaine may reduce dopamine activity only in animals or people previously exposed to addictive drugs, not in drug-naive ones. In three experiments with male Long Evans rats, 40 mg/kg ibogaine did not decrease preference for a sweet glucose + saccharin solution, nor did it attenuate conditioned flavor preference. However, ibogaine significantly lowered amphetamine-induced locomotion in rats that had received four prior doses of amphetamine, but not in drug-naive rats. The findings suggest ibogaine can reduce sensitized dopamine activity back toward baseline levels, potentially lowering drug craving in addiction.