Ibogaine and the dopaminergic response to nicotine.
Psychopharmacology February 1, 1997 I M Maisonneuve, G L Mann, C R Deibel et al. 38 citations
Intravenous nicotine infusions in rats increase extracellular dopamine in a dose- and order-dependent manner, with acute tolerance appearing when infusions are spaced one hour apart but not when spaced three hours apart. Pretreatment with ibogaine 19 hours before nicotine attenuates this dopamine increase, suggesting ibogaine may reduce nicotine's rewarding effect.