Acute and chronic administration of ibogaine to the rat results in astrogliosis that is not confined to the cerebellar vermis.
Annals of the New York Academy of Sciences October 31, 1996 J P O'Callaghan, T S Rogers, L E Rodman et al. 14 citations
High doses of ibogaine, a psychoactive alkaloid, damage brain regions beyond the cerebellum in rats, with effects depending on sex and dosage. Single doses caused dose-related increases in GFAP, a marker of brain cell injury, across multiple brain areas in both sexes. Repeated doses led to large GFAP increases (up to 200% of control) in the hippocampus, olfactory bulbs, brain stem, and striatum of female rats but not males. In the hippocampus of chronically treated females, other structural proteins also increased, suggesting a sprouting response to damage. The findings indicate that ibogaine's neurotoxic effects are not limited to the cerebellum and vary by sex and dosing schedule.