Role of hippocampal 5-HT1A receptors on elevated plus maze exploration after a single restraint experience.
Behavioural brain research May 1, 1996 S M Netto, F S Guimarães 45 citations
A compelling finding reveals that a systemic injection of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) can enhance exploration in an elevated plus maze after stress. In a study with rats, immediate post-stress treatment increased open arm exploration 24 hours later, while saline showed no effect. This enhancement was negated by pre-treatment with a selective 5-HT1A antagonist, suggesting that hippocampal 5-HT1A receptors play a critical role in mitigating the behavioral impacts of stress. These insights could inform future approaches to stress-related disorders.